Calcium channel blocker (CCB).
2 classes
- DHP (dihydropyridone)
- Non DHP
DHP = “ ‘dipines”
Amlodipine, Lercandipine, nifedipine
Reduce BP
Increase HR so not suitable in IHD
Can worsen protein leak in renal disorders.
Indic in HTN, cerebral spasm.
C/I in bradycardia, AV block, acute HF.
Non DHP – 2 types
Verapamil
Diltiazem
Indic in HTN, IHD.
As may lower HR, C/I with digoxin and BBlockers.
Side effects of all.
- Constipation
- Headache
- Flushing
- Oedema
- Dizziness